P‐34 A case of exfoliative erythema multiforme associated with herpes virus 1 infection in a European cat
Identifieur interne : 000588 ( France/Analysis ); précédent : 000587; suivant : 000589P‐34 A case of exfoliative erythema multiforme associated with herpes virus 1 infection in a European cat
Auteurs : C. Prost [France]Source :
- Veterinary Dermatology [ 0959-4493 ] ; 2004-08.
Abstract
A 2‐year‐old female domestic short‐haired cat was referred with a 1‐month history of extensive scaling and alopecic dermatitis. Clinical signs appeared suddenly 2 weeks after ocular and upper respiratory tract signs that were treated with amoxicillin and marbofloxacin. Physical examination revealed widespread scaling and alopecic dermatitis. The skin was firm with a cardboard‐like texture. The ocular and nasal mucous membranes were inflamed. The cat was lethargic and reluctant to move. FeLV and FIV tests were negative. Skin scrapings failed to reveal any evidence of ectoparasites and dermatophytes. Thoracic radiographs showed no abnormalities. Skin biopsy specimens were collected from the face and the trunk under general anaesthesia. Histopathologic examination revealed a lymphocytic interface dermatitis with many mast cells, severe hydropic degeneration of basal cells, and numerous apoptotic keratinocytes (with satellitosis) at all levels of the epidermis. The epidermis was hyperplastic with orthokeratotic hyperkeratosis and some foci of parakeratosis. Hair follicles were atrophic and a diffuse fibrosis was noted within the dermis. Ultrasonographic examination of the thorax and abdomen failed to reveal any abnormalities. PCR evaluation of skin specimens, as well as nasal and ocular discharges, confirmed the presence of feline herpes virus type 1. Antiviral treatments were implemented (aciclovir dosed at 50–100 mg/kg twice daily and ocular idoxuridine) with spectacular improvement. Unfortunately, the drugs had to be discontinued due to hepatic toxicity. Omega interferon was also used, but without success. A few months later, spontaneous recovery was observed. Funding: Self‐funded.
Url:
DOI: 10.1111/j.1365-3164.2004.00414_34.x
Affiliations:
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A case of exfoliative erythema multiforme associated with herpes virus 1 infection in a European cat</title><author><name sortKey="Prost, C" sort="Prost, C" uniqKey="Prost C" first="C." last="Prost">C. Prost</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>26 rue Des Tilleuls</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="51">51</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 2‐year‐old female domestic short‐haired cat was referred with a 1‐month history of extensive scaling and alopecic dermatitis. Clinical signs appeared suddenly 2 weeks after ocular and upper respiratory tract signs that were treated with amoxicillin and marbofloxacin. Physical examination revealed widespread scaling and alopecic dermatitis. The skin was firm with a cardboard‐like texture. The ocular and nasal mucous membranes were inflamed. The cat was lethargic and reluctant to move. FeLV and FIV tests were negative. Skin scrapings failed to reveal any evidence of ectoparasites and dermatophytes. Thoracic radiographs showed no abnormalities. Skin biopsy specimens were collected from the face and the trunk under general anaesthesia. Histopathologic examination revealed a lymphocytic interface dermatitis with many mast cells, severe hydropic degeneration of basal cells, and numerous apoptotic keratinocytes (with satellitosis) at all levels of the epidermis. The epidermis was hyperplastic with orthokeratotic hyperkeratosis and some foci of parakeratosis. Hair follicles were atrophic and a diffuse fibrosis was noted within the dermis. Ultrasonographic examination of the thorax and abdomen failed to reveal any abnormalities. PCR evaluation of skin specimens, as well as nasal and ocular discharges, confirmed the presence of feline herpes virus type 1. Antiviral treatments were implemented (aciclovir dosed at 50–100 mg/kg twice daily and ocular idoxuridine) with spectacular improvement. Unfortunately, the drugs had to be discontinued due to hepatic toxicity. Omega interferon was also used, but without success. A few months later, spontaneous recovery was observed. Funding: Self‐funded.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Prost, C" sort="Prost, C" uniqKey="Prost C" first="C." last="Prost">C. Prost</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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